This song has some top-notch insanity. Obviously this was released with hardcore players in mind. Definitely not for those still learning the ropes.
The guitar part takes a moment to start, since the intro is vocals and drums. Then we start with some simple three-HOPO patterns, usually ending with sustains. It changes up a bit halfway through the opening riff and adds in different patterns and HOPO chords.
And then the verse starts, and you're treated with nonstop, ascending HOPO arpeggios for about a minute. Then we get the first solo, which is essentially the same thing, but descending and with stylistic breaks. The ascending arpeggios come back for a bit, before going into the post-verse bridge. This is one out of two non-solo sections with awkward HOPO patterns that once you get down, become so much fun.
The second solo comes in, and at first it's deceivingly simple in comparison to all that's just hpapened, with plenty of sustains and slow HOPOs. Then suddenly really fast, descending HOPO triplets fly by at such a fast rate, and to top things off, you finish the solo with one of the longest trill lanes in Rock Band history. Makes sure to use both hands to tap this shit.
You have a break after that, then the chorus has some simple two-note HOPO patterns that descend before going into the post-chorus bridge. This is the second non-solo segment with awkward but fun HOPO patterns. The song then closes with more of the chorus, then a surprise final chord.
Truly masochistic in every way, this sure will bring a really fun challenge, if you're up for it.